The calculation of safety distance is an important component in the construction of LNG project. We should fully consider the public social security of the surrounding people and property and the safety of natural ecological environment in the calculation of safety distance. In this paper, the typical accident cases caused by insufficient safety distance in the domestic and international LNG installations are analyzed，and relevant domestic safety distance regulations, standards and requirements are compared. Finally, the existing methods for determining the safety distance in China are summarized. This paper proposes that the consequences of accidents should be chosen as the main basis, and the mathematical model as the analysis method to perform study on diffusion, fire, explosion and other conditions. From the perspective of quantitative risk, the safety measures to reduce the effectiveness of risk are determined，and suggestions for setting safety distance are also proposed. Through analysis, it is believed that the unit that has a great influence on the whole system should be selected, and the safety distance should be determined by quantitative analysis method based on accident consequences.