It’s very important to learn the key points and difficulties during the execution of safety life cycle(SLC) aiming at enhancing safe execution of oil and gas pipeline project, realizing the popularization and application of safety life cycle design and releasing the importance of safety instrument system (SIS) to safe project execution.After the exploring and execution of international standards strictly for oil and gas station project and basing on the stringent execution process and complicated roles play with many participants during safety life cycle design, the difficulties analysis comparing to international standards during the execution of safety life cycle have been completed, obtaining key control points and suggestions on execution of safety life cycle design.And the key control points and key parameter will still be the focus of safety life cycle design in the future.