The size of berthing ships at seaports varies, and the flow and pressure of the ships' built-in pumps are not fixed. When the distance between the dock and the storage area is far, and the pressure of the ships' built-in pumps is insufficient, multiple booster pumps need to be added at the dock. To cater for different sizes of ships, an operation plan of multiple pumps combination should be provided. Centrifugal pump is selected as the booster pump for this seaport. To address the issue of excessive force and torque on the pump nozzle under different operating schemes, in accordance to API 610 Centrifugal pumps for petroleum,petrochemical,and natural gas industries, the CAESAR Ⅱ stress analysis software is used, with the nearest anchor point of the pump unit as the analysis unit. The calculation method for the temperature of the standby pump piping is provided, and the pump along with its inlet and outlet piping are analyzed as a whole. Through detailed stress analysis of pump nozzle and pump inlet and outlet piping systems under various operating conditions, we have developed a piping arrangement that not only complies with industry standards but also enhances operational ease and maintenance accessibility, while presenting a clean and orderly aesthetic. This was accomplished by altering the piping systems route. This study provides meaningful guidance to piping arrangement of centrifugal pump under various operating conditions.