In order to ensure that high pressure natural gas pipeline systems at CNG supply stations and filling stations are intrinsically safe and reliable and ensure the safety of working personnel and facilities at the stations and surrounding residents, it is very important to reasonably design wall thickness of high pressure gas pipelines. In combination with relative requirements for high pressure (16~32MPa) gas pipeline system in current Chinese National Standards, conducted is systematic analysis on factors affecting high pressure compressed natural gas pipeline wall thickness calculation and it is suggested that the third strength theoretical calculating formula is used to calculate the wall thickness of high pressure pipelines at CNG filling stations.