In order to study design and operating parameters of TEG regeneration system in high altitude localities, simulation software HYSYS is applied to analyze the regeneration pressure of the system and results show that negative pressure has significant effect on regeneration system in high altitude localities. Heating temperature, reboiler load and flow rate of stripping gas are decreased significantly and linearly increased with local ambient pressure. Compared are the simulation results with actual application results from a gas field in continental plateau and the results show that the conclusion obtained from the software simulation is valid and has a certain guiding significance for regeneration system design and practical operation.