Stabilization of dry gas seal system is one of the basic guarantees for normal operation of centrifugal compressor. In order to optimize dry gas seal system conditions of centrifugal compressor, prevent misoperation and improve the dry gas seal system stability, in combination with the principle of dry gas sealing, supply gas categories and seal body structures, common faults and maintenance characteristics are studied and analyzed in normal and special working conditions. The results show that high quality feed gas, proper differential pressure of sealing gas and strict routing inspection and daily maintenance are basic elements for assuring stable operation of dry gas seal system. More attention shall be paid to alarm system and field instrument anomaly so as to take strict precautions against interlocking and the shutdown caused by instrument failure and artificial operation factors.