Relative literatures and accident statistics published at home and abroad in recent years show that in addition to the natural disasters such as earthquakes, landslides, etc., events closely relative to such human activities as wars, terrorist attacks and blasting construction have become important reasons of oil and gas pipeline damage and failure. Conducted are 3D dynamic numerical simulation on spread of blasting seismic waves and dynamic response of vibration process of buried oil and gas pipelines after accidental explosion of explosive storage and numerical analysis on simulation results and obtained are vibration speed response characteristics of the pipelines. Based on calculation results obtained in a number of different conditions, such as dynamite inventories of explosive storage, site media properties, materials and sizes of buried pipelines, etc., combined with quantitative analysis on vibration safety criterion, safety distances of buried pipelines are obtained in different conditions, which has important theoretical significance and application value for safe and proper operation of buried oil and gas pipelines.