In order to study the application feasibility of PVDF in oil and gas field, compatibility of PVDF in simulated oilfield atmospheres was studied by using autoclave. The change rules of weight, morphologies, mechanical property, composition and thermal resistance of PVDF before and after the tests were compared and analyzed systematically. Results revealed that the weight of PVDF increased in simulated heavy oil condition due to the swelling in tests, which caused a reduction of its Viral soften temperature and many nano-cracks on its surface. However, the change of weight gain and hoop tensile strength was much lower than the limit of standard. Moreover, no apparent changes to the composition and pyrolytic process were observed, further revealing that PVDF had a perfect applicability in simulated oilfield environments.