Science and technology promote the development and progress of human society. Under the new situation, the enterprise plays an increasingly important role as the main body of social science and technology innovation. Through the development of scientific research projects, Company C has formed a certain foundation. However it also appears some problems. Having studied the PMBOK advanced by PMI, in order to solve these problems, enhance the management level, this paper combines the characteristics of engineering projects and points out the differences and worth learning aspects of PMBOK model when applied to scientific research project management, especially in engineering and construction fields, to propose scientific and technological project management knowledge model: T-PMBOK. Through analyzing the management process of a typical scientific research project running in Company C, this article summarizes 5 issues such as repeated projects, poor channels to funds, quality control difficulty, slow customer response, multi-project conflict, and provides 5 management strategies such as business restructuring, streamlining channels, applying quality management tools, increasing market sensitivity, promoting project management information systems by using T-PMBOK.