The reliable operation of injection-production wells is one of the key elements for the safety of the underground gas storage (UGS). It is necessary to use the safety control system of wellhead for the security production. Influenced by intensive injection and production, a higher requirement is proposed for wellhead safety control system. Focused on the characteristics of UGS and the overall concept of security control, which includes the remote control terminal, the ESD system in the well site and hydraulic control system in the wellhead, this paper designed a system safety control system with such functions as remote emergency shut-in, low-pressure automatic shut-in and fire shut-in. The site practice has proved it to be reliable and easy to be operated, which could provide safe and smooth operation for the 14 injection-production wells in the UGS of Wen 96.