With the economic development and social progress, the foundation treatment technology has been more and more widely used. In this paper, the application of comprehensive ground technology in engineering is studied for severely uneven grade IV (highest grade) self-weight collapsible loess and 8 degree seismic fortification geology.Through the analysis of the geological data of the preliminary survey, a preliminary plan was selected based on the principle of safe and economic, convenience of construction operation and monitoring.After a series of dynamic compaction and trials compaction, based on the testing result of pile foundations, a variety of foundation treatment technologies were used. Finally, a foundation treatment plan was confirmed, and a project investment of 46 million yuan was saved.Through the practice of this project, it has been fully proved that the comprehensive use of multiple foundation treatments is not only technically feasible, but also has significant economic and social benefits.