Oil pump pipeline is one of the key equipments in oil production.Whether it can run normally is related to the operation of the whole device directly.The finite element model of the export pipeline of oil pump is established based on ANSYS.Firstly, modal analysis is carried out on the outlet pipeline of the oil pump to get the natural frequency and different order mode of vibration of the pipeline model.Secondly, the thermal-stress coupling analysis is carried out to obtain the stress and strain of the outlet pipeline.Thirdly, the bi-directional fluid-structure coupling calculation is carried out in this paper, and the interaction between fluid and pipeline is analyzed to obtain the periodic vibration frequency of pipeline at different times.At last, different vibration reduction measures are proposed according to the results of numerical calculation and field test.By comparing the vibration of the pipeline before and after the improvement, it is pointed out that the vibration of the outlet pipeline of the oil pump has been greatly improved, which shows that the method can effectively reduce the vibration of the pipeline and provide reference for similar projects.