The rough helium separation system is the main source of energy consumption in the helium extraction from natural gas process.How to reduce the process energy consumption while ensuring the product quality is an important research topic.A process parameter optimization strategy for rough helium separation system based on exergy analysis is proposed to achieve energy consumption reduction.Firstly, the weak energy segments are evaluated based on exergy analysis approach.Then the key parameters are optimized for the minimal exergy loss of the system.Hence, the energy consumption of the system is reduced farthest when the yield of rough helium is still high enough.Besides, a key process parameter identification strategy based on sensitivity analysis is proposed to reduce the computational complexity of the optimization process.The research results show that the total exergy loss of the system is reduced by 11.01%, and the total energy cost is reduced by 11.82% afterprocess parameter optimization, which has achieved good energy saving and consumption reduction effects.