With the development of industrial Internet of Things, the past closed industrial control system of oil and gas processing plants is gradually incorporated into the industrial Internet of Things system.The network security protection strategy of industrial control systems of oil and gas processing plants becomes more and more important.The architecture and setting of industrial control systems network security protection has direct effect on whether the industrial control system can run normally and safely, and also on the economic benefits and safety of the plant.In this paper, for the industrial control system set up in the oil and gas processing plant, the system configuration in the design phase is discussed from the network architecture and the network security protection strategy, whichprovides reference for the design of industrial control system in similar plants in the future.