At present, LNG road tankers are mostly loaded manually, and the loading process is complicated, involving many procedural steps and valving sequences, and very demanding on operators physical strength in moving the loading arms. As a result, the intense work load of this operation brings both physical and mental fatigue to the operators, and that can easily result in over filling of the road tanker and cause the lifting of the safety relief valve. To improve the production operation mode involving LNG road tanker, reduce cost and increase efficiency, and achieve delicacy management; smart LNG road tanker loading system is developed. This smart system includes road tanker loading skid, quick coupling for connection with the road tanker, upgrade of tanker instrumentation and road tanker management procedure control system. With this new system, the loading process of LNG road tanker is easily operated, automatically monitored, and controlled via artificial intelligence. Thus, the operators’ manual work intensity is reduced, and the safety of the LNG truck loading process is enhanced. This new system can provide a basis for the research of fully automatic loading arm for tanker loading skid, and finally achieve the remote operation with visual monitoring of the unmanned road tanker loading area, and can also serve as a technical resource for research in the field of new smart road tankers and the future batch tank loading operations.