Among many natural gas desulfurization technologies, adsorption desulfurization is more widely used because of its simple, convenient and economic characteristics. To investigate the removal effect of multi-component organic sulfur in natural gas by adsorption desulfurization, this paper conducted removal tests with 13X molecular sieve as solid adsorbent to remove seven organic sulfur components(including methyl mercaptan, ethyl mercaptan, propyl mercaptan, COS, CS2, dimethyl sulfide and thiophene) from high sulfur natural gas. Dynamic adsorption method is used to investigate the effects of adsorption pressure, adsorption temperature, number of regeneration cycles and gas space velocity on the sulfur penetration capacity of these seven kinds of organic sulfur on adsorbents. By analyzing and comparing the tests results, it is concluded that:1)there is adsorption competition phenomenon in this multi-component organic sulfur removal process by 13X molecular sieve;2)13X molecular sieve has good removal performance for mercaptan, dimethyl sulfide and thiophene, and can be used for industrial desulfurization;3)within the appropriate range, higher adsorption pressure, lower temperature and lower gas space velocity are more conducive to the removal of organic sulfur. The research results could provide references for sulfur removal technologies in similar engineering projects in the future.