The comprehensive utilization of hydrogen has been a research hotspot in countries all over the world in recent years, and it is also one of the important development directions of new energy in the world. When hydrogen is transported in bulk on a large scale, pipeline transportation is more efficient and safe. About 6 000 km of hydrogen pipelines have been built abroad and some countries have blended hydrogen into natural gas pipelines to achieve long-distance transportation and utilization of hydrogen, and have developed some relevant pipeline standards. However, there are no relevant standards for hydrogen/hydrogen-blended natural gas long-distance pipelines in China. Due to the differences in design concepts, it is impossible to refer to foreign regulations on the issue of station layout equipment spacing. At the same time, for systems handling gas mixtures with different hydrogen/natural gas concentrations, whether the pipeline's potential impact radius and explosion-proof area scope specified by relevant foreign regulations are reasonable remains to be verified. Based on the physical characteristics of hydrogen and hydrogen-blended natural gas, combined with the essential principles of the separation distance between natural gas pipelines and equipment in station yards, the influence range of hydrogen, hydrogen-blended natural gas and natural gas is quantitatively assessed and compared, and some reference bases for the engineering design of hydrogen-containing pipelines are discussed. Studies have shown that the fire separation distance of hydrogen-containing natural gas stations can refer to the relevant regulations of natural gas stations. The potential impact radius of hydrogen-blended natural gas pipelines could be underestimated by following the equation of pure hydrogen pipelines. To rectify this situation, the modified quantitative calculation method proposed in this paper can be used. The area classification for hydrogen-blended natural gas pipelines and stations should implement relevant requirements for hydrogen and natural gas station. The research results can provide a reference for the engineering design of hydrogen-containing pipeline.