Aiming at the problems of serious vertical interference, imperfect well pattern and unbalanced displacement in the ultra-high water cut stage in block T of S oilfield, a near resistance combination optimization method with pseudo seepage resistance parameter as the main index is established longitudinally according to reservoir engineering theory and mathematical optimization method. The vector well pattern of differential control and injection production optimization method with minimizing the variance of average water saturation as the objective function are established on the plane. Based on this optimization method, the adjustment ideas and countermeasures of vertical near resistance combination optimization, plane vector well pattern and vector injection production optimization are put forward in field test. After adjustment, the recovery rate of T block reservoir has been increased by more than 3.2%, and the field application effect is remarkable. The research results provide guidance and reference for the development and adjustment countermeasures of oil fields in ultra-high water cut stage.