Foam resistance factor and residual resistance factor are important parameters to characterize the profile control and plugging effect of foam flooding, but they may be affected by many factors such as core permeability, porosity, and foam injection amount. A large number of indoor evaluation experiments are required to obtain the effective foam resistance factor and residual resistance factor. Through SPSS software, the relationship between foam resistance factor and residual resistance factor and each factor is fitted using stepwise regression method. The influence rule of each factor on foam seepage resistance factor is obtained, and the interaction between each factor is analyzed. At last, the prediction model, with an accuracy of more than 80%, was obtained by combining the experimental data. The study provides a reference for the calculation of the foam resistance factor and the residual resistance factor in the indoor evaluation experiment.