The existence of hydrogen will cause deterioration in pipeline mechanical properties and threaten the safe operation of subsea pipelines. This paper considers the main mechanical properties required by the hydrogen subsea pipeline, including tensile performance, fracture toughness, and fatigue crack growth. By studying the main factors related to the hydrogen embrittlement, materials selection of hydrogen subsea pipeline has been discussed in details. The study results show that:1) The hydrogen impact on steel’s tensile properties is mainly ductility decrease;2) Considering the risk of hydrogen embrittlement for welds, seamless steel pipe is recommended if cost allows;3) optimization on grain size and micro structure uniformity will increase the fatigue resistance of line pipe;4) The increasing of steel’s fatigue crack growth rate induced by hydrogen is inevitable. The fatigue crack growth rate is not only related to the inherent properties such as fracture toughness, strength and microstructure, but also influenced by the actual stress level. Therefore, on the premise of ensuring sufficient ductility and high fracture toughness of the material, it is necessary to reduce the stress level to improve the stress intensity factor required for crack initiation and fracture toughness at stage Ⅲ of fatigue crack propagation, and to delay the crack growth and increase the fatigue life of the material.