As a kind of pressure boosting equipment, motor-driven centrifugal pump and compressor are widely used in engineering. Its speed regulating scheme is mostly mechanical or frequency conversion type. However, these two types of scheme have some problems such as low efficiency, stringent requirements on installation environment and the presence of electromagnetic radiation. In order to optimize its speed regulating performance, it is necessary to analyze the operating characteristics and requirements of centrifugal pump and compressor, and explore new speed regulating scheme. This paper introduced a new speed regulating scheme for high-power electric motor-driven centrifugal pump: speed mechatronics engineering. This paper analyzed the structure, working principle, working mode, starting mode, working efficiency, safety and reliability, and practical application in many industries of this new speed regulating scheme, and compared it with the traditional mechanical speed regulating scheme and frequency conversion scheme through a project casestudy. It shows that the new speed regulation scheme has the advantages of both mechanical speed regulation and frequency conversion regulation, and achieves efficient transmission, high reliability operation and low maintenance cost, improving the system efficiency and meeting the objectives of energy saving and emission reduction. The research results can provide relevant references for the optimization direction of electric motor-driven centrifugal pump speed regulating scheme of oil and gas pipeline projects.