Hydrogen transportation cost restricts the development of the hydrogen energy industry. In order to solve this problem, a certain proportion of hydrogen is injected into the existing, relatively complete natural gas pipeline network for transportation. This approach has great engineering application value and received widespread attention. Moreover, Under certain hydrogen-doped ratio of hydrogen-enriched natural gas can be directly utilized as fuel, which contributes to an increase in the proportion of hydrogen energy utilization and reduce NOX emissions. This paper focuses on the design of natural gas and hydrogen blending process and the process safety in control of hydrogen blending system operation. The research results can provide reference for the promotion and application of hydrogen-enriched natural gas technology.