In the shale gas dehydration process using solution absorption, the loss of absorption solution is the key control parameter for design and operation of this process. If the loss is large, on the one hand, the product gas will carry over the solution mist droplets. Precipitation would occur in the form of solid impurities due to changes in pressure, temperature, flow rate, flow pattern and pipeline corrosion during the gas transportation process, causing particle erosion and even blockage of downstream pipes and valves. On the other hand, the loss of absorption solution requires the continuous fresh replenishment, which greatly increases the operating cost of the dehydration operation. In order to analyze the factors causing solution loss and find out the effective measures to reduce loss, physical property research, engineering simulation, operating condition changes are carried out. Some measures to reduce solution loss are proposed, such as selecting optimum temperature and pressure of raw gas, deep pretreatment of impurities in the raw gas, installing high efficiency gas-liquid filter downstream of the gas outlet of the absorber, selecting optimum location of temperature measuring point for reboiler temperature, selecting suitable stripping gas volume in the regeneration process. The research findings provide a good reference for ways to reduce absorption solution loss via carryover from the dehydration system.