Brent is one of the most important pricing benchmarks in the global crude oil market. Over the past forty years, due to the decline in production of deliverable crude oil grades in the Brent pricing system, new grades have been continuously included in the Brent pricing system to ensure liquidity. Midland crude oil which is a type of crude oil produced in North America, is closely related to another global benchmark for crude oil, WTI (West Texas Intermediate). The participation of Midland crude oil in Brent pricing system is similar to no other event in the past, which may have a structural impact on the crude oil market. Based on qualitative analysis of the impact of the addition of Midland crude oil to the Brent pricing system, this article studies its impact through quantitative methods. The study suggests that:1) the correlation between Brent and WTI prices will be stronger in the future;2) the price difference between Brent and WTI will be structurally narrower than before;3) while the influence of the United States on the oil market increases, the influence of Brent prices in the global oil market is also expected to further increase. It is recommended to closely monitor and assess the impact of the introduction of Midland into Brent pricing system, and take proactive measures in advance; actively cultivate domestic crude oil spot assessment institutions to improve the transparency of domestic crude oil spot trading; attach great importance to enhancing the influence of domestic crude oil futures and continuously improve the construction of institutional mechanism of the domestic crude oil futures market.