The offshore low-permeability reservoirs feature a large vertical span and the development of thin interbedded layer. If the conventional general fracturing is adopted for reservoir transformation, the competition between multiple clusters of fractures can lead to inadequate transformation of some thin oil layers, resulting in rapid decay of fracturing production. If mechanical stratification is adopted, the weak sealing capability of the separator can lead to sand jamming in the strings due to reservoir breakthrough, and the contradiction between high input and low output is prominent. To address these challenges, the fine clustering technology based on geological and engineering dual dessert was used to perforate the transformation section. The fluid distribution into each cluster of orifices in the section was improved by temporary plugging at the fracture opening. By optimizing the temporary plugging parameters, the balanced initiation of multi-cluster fractures was realized. Low-damage, high-temperature seawater-based fracturing fluids are selected to reduce reservoir damage and offshore fluid costs. High-frequency pressure monitoring technology enables real-time interpretation of multi-cluster fracturing inlet points. Finally, the “fine clustering+temporary plugging and uniform expansion+high-frequency monitoring” multi-cluster temporary plugging and flow-controlled fracturing technology suitable for offshore low-permeability silty clay interbedded layer has been developed. The first application of this technology offshore has achieved the significant increase in production, with daily oil production of exceeding 100 m³/d, which is 5 times higher than that of conventional general fracturing wells. The implementation results show that the multi-cluster temporary plugging and flow-controlled fracturing technology can effectively improve the inter-cluster production rate and transformation degree of thin interbedded layer, providing robust technical support for the economic and effective development of offshore low-permeability reservoirs.