The reservoir with high temperature and high salinity in Lunnan oil field TI group of Tarim has been found with ineffective water circulation, and serious water channeling because of water absorption differences between TI2 and TI3,especially absorbent water absorption of TI3 group. On the basis of laboratory experiments, two batches of tests including 9 well groups with large dosage overall deep profile control technology had been carried out,and remarkable test effect had been obtained. The direct and indirect cause of affecting the overall displacement effect of Lunnan oilfield has been found out by analyzing the subjective and objective factors, such as reservoir physical propertie,preferential migration passage,waterflood condition,injection-production relationship,remaining oil distribution,conversion time and deficit of stratum,particle size,reagent dosage. The result of research shows that the remaining oil accumulation areas with good material foundation, large reservoir cavity loss, large reservoir thickness, good reservoir physical property, strong connectivity and weak heterogeneity should be selected for well flooding objectively; Subjectively the low injection pressure, good layer corresponding relationship, bidirectional or multidirectional well, but not single well group should be selected in the independent closed blocks of overall displacement. The particle size of the regulating agent must be well matched with the pore throat of the formation,there is a close relationship between dosage and driving radius. This paper provides reasonable basis for well selection profile control and construction.