Generally, clastic rock reservoirs in LN oilfield and ST oilfield inTarim Basin are of middle  porosity and middle permeability, the thin aqueous layers occur frequently and  bottom water are active, high quality of zonal isolation is required. In the process of cementing, fluid communication is easy to occur, and micro gaps are easily to appear to cement annulus, also lead to high moisture in the future oil and gas production. Self healing cement has self repairing function, and has a certain micro expansion effect, which can effectively prevent the channeling flow and improve the interfacial bond. Considering the difficulties in clastic rock cementing, combining with the characteristics of self-healing cement, we developed a self-healing cement slurry for this block. The cement slurry has good liquidity, high compressive strength, short transition time in static gelling, and so on. Through the indoor experiment and the successful application to 4 wells, it shows that the self-healing cement slurry system can satisfy the requirements of clastic rocks cementing, significantly improve the cementing quality. The high quality rate of reservoir section is over 70%, and the rate of water content of two wells is 0%， which provides a strong guarantee for the stability and efficiency exploitation of the old oil field.