The outer diameter and wall thickness of pipeline are important parameters in pipeline design. But due to the limitation of the existing technology, there will be a deviation from manufacturing tolerances of the outer diameter and wall thickness in the pipeline production process, which will have certain impact on pipeline reliability. In order to study the influence of deviations from manufacturing tolerances of outer diameter and wall thickness on pipeline reliability, this paper obtained the data of pipe outer diameter and wall thickness by pipeline geometry dimension measuring instrument, and studied the distribution law of pipe outer diameter and wall thickness. The limit state-function for calculating pipeline pressure is established and the reliability calculation formula considering the influence of deviation from manufacturing tolerances of pipeline is derived by using first-order second-moment method. On this basis, the influence of average and standard deviation of pipe outer diameter and wall thickness on pipeline failure probability was studied, and the sensitivity of pipeline failure probability to the geometric parameters was analyzed. The results show that the deviation from manufacturing tolerances of outer diameter has little influence on pipeline reliability, while that deviation of wall thickness has relatively large influence on pipe reliability. Therefore, the deviation from manufacturing tolerances of wall thickness should be strictly controlled in the process of pipeline production.